Project Description

We will study the contribution of the vascular compartment in the castration-naïve metastatic PCa, encompassing a tumour type that is metastatic at the time of first diagnosis. Specifically, we aim to: 1) identify critical molecular changes in the stroma of metastatic prostate cancer through computational and clinical analysis; and 2) conduct co-culture analysis with modify stroma and transformed epithelium, as well as in vivo modification of the stroma in murine models of prostate cancer. The nature of the stromal contribution to the progression of the disease will be mechanistically deconstructed and exploited for the development of therapies.